MOXA NPort 6650-16-G2 Introduction
The Moxa NPort 6650-16-G2 Serial-to-Ethernet Device Server delivers a practical networking solution for organizations seeking to modernize their serial communication infrastructure while maintaining compatibility with existing equipment. Developed for industrial systems that require dependable connectivity and centralized device management, it allows businesses to extend the lifespan of legacy assets and streamline communication across distributed networks.
The model represented by part number NPort 6650-16-G2 includes 16 dedicated RS-232/422/485 serial ports, making it suitable for connecting industrial controllers, monitoring systems, and serial devices. High-speed communication is supported through 2 Gigabit RJ45 interfaces with configurations expandable up to 4 Ethernet ports, enabling flexible deployment. A robust metal body construction helps withstand demanding industrial environments, while the integrated microSD slot supports cards up to 2 TB for expanded storage requirements. With an operating range of -10 to 60°C, the device is designed for stable long-term operation. Positioned within the Terminal Servers category, it supports efficient serial-to-Ethernet networking.
MOXA NPort 6650-16-G2 Certifications

MOXA NPort 6650-16-G2 Features
- Ethernet Ports: 2 x 10/100/1000M RJ45
- Serial Standards: RS-232/422/485
- SD Slot: microSD card Up to 2 TB (high speed, 25 Mbps)
- Metal body
- -10 to 60°C operating temperature
Explore the wide variety of industrial automation products we have for sale at lower prices. Choose and buy MOXA NPort 6650-16-G2 Serial to Ethernet Device Server, ideal solutions that meet your specific needs. Our branches in the Middle East (UAE (Dubai, Abu Dhabi), KSA (Al Khobar, Riyadh), Kuwait, Qatar, and Oman) are strategically located to provide efficient support for all your purchasing requirements.
| serial-to-ethernet : Interface | |
| 10/100Mb RJ45 (Megabit) Ports | Yes: 2 ports (up to 4) |
| Digital Output Channels | - |
| Alarm Contact Channels | - |
| Magnetic Isolation Protection | 1.5 kV (built-in) |
| Protocols | TLS, SSH |
| serial-to-ethernet : Serial port specifications | |
| Flow Control | None, RTS/CTS, DTR/DSR, RTS Toggle, XON/XOFF |
| serial-to-ethernet : Communication details | |
| Wireless Standards | - |
| Maximum data transfer speed | - |
| Maximum direct range | - |
| serial-to-ethernet : Serial Interface | |
| Number of Ports | 16 Ports |
| Serial Standards | RS-232/422/485 |
| Connector | 8-pin RJ45 |
| Console Port | - |
| serial-to-ethernet : General | |
| Management | ARP, DHCP Client, DNS, HTTPS, ICMP, IPv4/IPv6, SMTP, SMTPS, SNMPv1/v2c/v3, SNTP, TCP/IP, UDP, WINS |
| MTBF | 29,321 hrs |
| Compatible operating systems | - |
| Fixed TTY Drivers | macOS versions: 14, 13, 12, and 11 |
| Linux Real TTY Drivers | Kernel versions 6.x, 5.x, and 4.x |
| Automatic Reboot Trigger | Built-in WDT |
| serial-to-ethernet : Serial Communication Parameters | |
| Data Bits | 5, 6, 7, 8 |
| Stop Bits | 1, 1.5, 2 |
| Parity | None, Even, Odd, Space, Mark |
| Baudrate | 50 bps to 921.6 kbps (supports non-standard baudrates) |
| Isolation | - |
| serial-to-ethernet : Power Requirements | |
| Connection | - |
| Input Voltage | AC models: 100 to 240 VAC, DC models: ±48 VDC (20 to 72 VDC, -20 to -72 VDC) |
| Input Current | 320 mA (max.) |
| serial-to-ethernet : Security | |
| Security | HTTPS (TLS 1.2/1.3), SNMPv3, SSHv2 |
| Encryption | HTTPS: ECC-256, ECC-384, ECC-521, RSA-1024, RSA-2048, RSA-3072, RSA-4096, AES-128, AES-256, CHACHA20, SHA-256, SHA-384, HMAC, SSH: ECC-256, ECC-384, ECC-521, RSA-2048, AES-128, AES-256, SHA-256, SHA-384, HMAC SNMPv3: AES-128, SHA-256, SHA-384, Secure OP mode: HTTPS: ECC-256, ECC-384, ECC-521, RSA-1024, RSA-2048, RSA3072, RSA-4096, AES-128, AES-256, CHACHA20, SHA-256, SHA-384, HMAC, Config import/export: AES-256, SHA-256, HMAC |
| Authentication | Local database, RADIUS, TACACS+ |
| serial-to-ethernet : Serial Signals | |
| RS-232 | TxD, RxD, RTS, CTS, DTR, DSR, DCD, GND |
| RS-422 | Tx+, Tx-, Rx+, Rx-, GND |
| RS-485-4w | Tx+, Tx-, Rx+, Rx-, GND |
| RS-485-2w | Data+, Data-, GND |
| serial-to-ethernet : Features and capabilities | |
| Display | - |
| serial-to-ethernet : Physical Characteristics | |
| Installation | Desktop, Rack mounting (RK-43-01, included in the box) |
| Standards and Certifications | EMC, EMI, EMS, NEMA TS2, IEC 62368-1, UL 62368-1, EN 62368-1, IEC 60068-2-6, ISTA 1A, RoHS, CRoHS, WEEE, Telcordia Standard SR-332, Telcordia SR-332 Issue 4 |
| Housing | Metal |
| Operation Humidity | 5 to 95% (non-condensing) |
